As I mentioned in the Philosophy of Science thread, there is this thing called the pessimistic meta-induction that counsels that because all our past theories have been demonstrated to be strictly or wholly false, we should have a little humility, and expect inductively that all our current theories may also be strictly or perhaps even wholly false.
A current example: General relativity and quantum mechanics are great theories in their own domains.
Well, there's false, and then there's false. Newton's Universal Gravitation was falsified and replaced by General Relativity; But that didn't mean that rocks suddenly started falling upwards or sideways.
A good theory is an approximate model of a part of reality. The better an approximation of reality it is, and the more of reality it encompasses, the less likely it is to be wildly wrong without anyone noticing yet.
As time goes on, more and more of our earlier theories are shown to be strictly false, and fewer and fewer are shown to be wholly false.
It is reasonable to predict that if and when a new theory replaces GR or QFT or both, that it will predict almost identical results to its predecessors, in their respective domains; Indeed, it would be unreasonable to predict that it will not.
Technology advances by increasing options - we develop new ways to exploit scientific principles, and so we tend to think of science and technology as providing new ways to do stuff, and ways to do stuff we couldn't do before.
But science and tecnology are dissimilar in this regard. Science does not provide new ways to do stuff - it just tells us which of our old guesses were mistaken. The strength of science is not in what it makes possible, but in what it rules out as a waste of time.
Technology advances and lets us do more; Science advances and lets us rule out more dead ends.
Medieval technologists wasted a lot of time and effort trying to build perpetual motion machines, or to use chemistry to turn lead into gold. Modern science tells us that these things are futile; If we want cheap energy, we need to get it from somewhere else, and if we want to turn lead into gold, we need nuclear reactions, not chemical ones.
Science doesn't make more things possible, and it never did. It makes fewer things possible, thereby allowing technologists to see the wood for the trees.