Is Science Hitting a Wall?, Part 1 - Scientific American Blog Network Is Science Hitting a Wall?, Part 2 - Scientific American Blog Network
From the first one,
It may depend on what counts as a breakthrough. Could many breakthroughs be evident as breakthroughs well in retrospect?
Also, as author John Horgan notes, it could simply be that the easier stuff has already been done. Improved technology likely mitigates this problem, but apparently not enough.
I think that those biologists are right. There is a big biological mystery that has yet to be solved: how organism development works. We have such tantalizing hints as Hox genes, but not much more.
The second one discusses how drug development has become more difficult:
Eroom’s Law. The paper notes that “the number of new drugs approved per billion U.S. dollars spent on R&D has halved roughly every 9 years since 1950.”
The better than the Beatles problem.
The cautious regulator problem.
The throw money at it tendency.
The basic-research-brute force bias.
The devil is in the details problem.
John Horgan mentions a solution: "Appoint Dead Drugs Officers." To see what went wrong in a drug-development failure.
In theoretical science, one could appoint a "Dead Ideas Officer", one that could come after the likes of Freudian psychoanalysis and string theory.
I don't see why we should expect discovery to come out as a linear function of the size of the scientific workforce and cost of their scientific equipment. There's no way to tell a priori how far we are from the next big thing to discover.
That has always been true. What's different nowadays is that science is to some extent integrated into the capitalistic system of production, and certainly more than at the time of Newton or even Einstein. This would explain why there are now economists, rather than scientists, looking into, and complaining about, the rate of discovery of current scientific research.
Yet, given the impact scientific discoveries have had on the world, political leaders are not going to question the necessity of investing more and more hard money into science. What they have to do, and are largely already doing, is try and identify research that's not necessary and then they can decide to cut the money for that. Yet, nobody has any rational way to make this call for some particular lines of fundamental research, things like the String Theory for example. And so it will go on and on unless there was a very serious set back in the economy or in the political stability of the world.
That being said, it should be expected that there are all manners of inefficiencies in current science, and announcing very loudly that science cost a lot more today and finds less and less may be a good starting point for looking into these inefficiencies and sacking a few people. Still, it's not going to change all that much overall.
I suspect it comes a bit too early. Give it again a few decades and it's possible political leaders then will be more uncomfortable than ours today spending big money on science if in the intervening period no major discovery has been made.
If science keeps making no major discovery in the years to come, less people will want to go into science. I think this has already been happening for quite some time now. It will just get worse. It's just a part I think of a general trend whereby the brightest among young people tend to become more and more motivated by the prospect of making big money than making some major scientific discovery. Science will loose out to finance. Less bright minds means a longer time to the next big discovery and at some point, it will feel just too much to assume for political leaders.
Then again, people like Newton and Einstein have shown you can make major discoveries outside big budget science. Einstein wasn't even a paid scientist when he started to work on Relativity. Humanity will always have original minds.
Anyway, we really don't know what's just behind the next corner, if anything.
And I will also guess that given the way our economy works, we really can't afford to miss out on any potential discovery.
Unless we're really, really stupid.
I mean, even more than I think we are.
EB
EDIT: You can think of it as a hostage situation. The world is hostage to the prospect of some potential major discovery.