Didn't the Natives fight back from time to time and lose? Is there any place on the planet which isn't inhabited by the victors of some war or another as opposed to the people who were there before that war? There's probably a few, but not all that many.
This is actually the direction I was looking in, less of an economic perspective and more of a cosmic perspective. Is there any lesson or moral to be learned other than 'it's a dog-eat-dog world'?
The interesting aspect about the invasion to me is that it happened when the world as a whole was in a different era. The social norms that allowed it to happen back then have now (mostly) evolved to become more humane. So if you look at it from an economic perspective you can't really draw a parallel between the Europeans of the 16th century and the Europeans of the 21st century, the two groups aren't contiguous so you can't penalize one based on the wrong-doings of the other.
Maybe another moral or lesson is that a lot of really weird, fucked up stuff happened in the past, but that's not exactly who the human race is any more.