Medical news

[brewer]

Risk of Severe Arboviral Disease in Patients Receiving B Cell-Depleting or Modulating Medications

The Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to share information and notify clinicians, public health authorities, and the public about the risk of severe arboviral neuroinvasive disease among patients who are receiving B cell-depleting or B cell-modulating medications, particularly anti-CD20 monoclonal antibodies (mAbs). Patients and their providers should be aware of this risk to help patients protect themselves against the bites of mosquitoes and ticks, which can increase patients' risk of arboviral disease.
...
In recent years, a novel clinical presentation of chronic, neurodegenerative encephalitis developing over months to years has been described in at least five patients receiving rituximab who were infected with an orthobunyavirus, including Jamestown Canyon virus, Cache Valley virus, or Potosi virus. All patients died; diagnoses were delayed because of unrecognized infection and rare or unexpected pathogens requiring specialized diagnostic testing.

Risk of Severe Arboviral Disease in Patients Receiving B Cell-Depleting or Modulating Medications

Risk of Severe Arboviral Disease in Patients Receiving B Cell-Depleting or Modulating Medications

www.cdc.gov

Anti-CD20 monoclonal antibodies — which include rituximab and its biosimilars, ocrelizumab, ofatumumab, ublituximab, obinutuzumab, and ibritumomab tiuxetan. Anti-CD20s, used to treat non-Hodgkin lymphoma, several leukemias, rheumatoid arthritis, pemphigus vulgaris, some types of vasculitis, multiple sclerosis (MS), and prevention of transplant rejection.

 

[crazyfingers]

What do you think about this?

I think that I don't know anything about it. But if Trump appointed people had anything to do with this alert I'd call it suspect. If only professional civil employees put this out I'd trust it.

 

[brewer]

Probably influenced and paid for by the big DEET consortium.

 

[thebeave]

Probably influenced and paid for by the big DEET consortium.

Big DEET. Just when I thought I heard it all.

 

[GenesisNemesis]

Probably influenced and paid for by the big DEET consortium.

I'm going to need the deets on that.

 

[Elixir]

Probably influenced and paid for by the big DEET consortium.

What’s the connection to DEET?
I did a lot of reading about DEET and it’s tox testing (mainly on rats) back in the 90s when the Company I was VP of, was bought by Wisconsin Pharmacal (now “Pharmacal”)
J&J was “big DEET” at the time … don’t know if that has changed, but WP was a main player.
The toxicology lit was quite surprising. It took an equivalent of a 150lb adult human consuming (orally) an ounce a day of pure DEET for measurable symptoms to show up, headlined by “loss of appetite”. The neurological studies didn’t turn up anything significant even at those levels of exposure.
I’m sure more studies have been done since then (there were a lot of companies poised to pounce if DEET were found to be really bad, esp if it were to be pulled off the market) so I wonder - what’s the latest, 30 years later?

 

[brewer]

What’s the connection to DEET?
I did a lot of reading about DEET and it’s tox testing (mainly on rats) back in the 90s when the Company I was VP of, was bought by Wisconsin Pharmacal (now “Pharmacal”)
J&J was “big DEET” at the time … don’t know if that has changed, but WP was a main player.
The toxicology lit was quite surprising. It took an equivalent of a 150lb adult human consuming (orally) an ounce a day of pure DEET for measurable symptoms to show up, headlined by “loss of appetite”. The neurological studies didn’t turn up anything significant even at those levels of exposure.
I’m sure more studies have been done since then (there were a lot of companies poised to pounce if DEET were found to be really bad, esp if it were to be pulled off the market) so I wonder - what’s the latest, 30 years later?

The connection is arbovirus (arthropod-borne virus) transmitted by mostly mosquitoes and ticks where I'm at. DEET is the active repellant (i.e. Deep Woods Off). Applied to the skin or clothing to keep the biting critters away. We use it when we're off road with the dog(s) or out playing golf.

 

[thebeave]

Probably influenced and paid for by the big DEET consortium.

What’s the connection to DEET?
I did a lot of reading about DEET and it’s tox testing (mainly on rats) back in the 90s when the Company I was VP of, was bought by Wisconsin Pharmacal (now “Pharmacal”)
J&J was “big DEET” at the time … don’t know if that has changed, but WP was a main player.
The toxicology lit was quite surprising. It took an equivalent of a 150lb adult human consuming (orally) an ounce a day of pure DEET for measurable symptoms to show up, headlined by “loss of appetite”. The neurological studies didn’t turn up anything significant even at those levels of exposure.
I’m sure more studies have been done since then (there were a lot of companies poised to pounce if DEET were found to be really bad, esp if it were to be pulled off the market) so I wonder - what’s the latest, 30 years later?

Yeah, DEET is surprisingly safe. Seems kind of counterintuitive given its nasty"chemical" smell and appearance.

Loss of appetite, you say? Sounds like drinking a can of DEET a day could be a safe off label weight loss drug. Maybe I'll give it try. Got a few pounds to lose.

 

[Elixir]

What’s the connection to DEET?
I did a lot of reading about DEET and it’s tox testing (mainly on rats) back in the 90s when the Company I was VP of, was bought by Wisconsin Pharmacal (now “Pharmacal”)
J&J was “big DEET” at the time … don’t know if that has changed, but WP was a main player.
The toxicology lit was quite surprising. It took an equivalent of a 150lb adult human consuming (orally) an ounce a day of pure DEET for measurable symptoms to show up, headlined by “loss of appetite”. The neurological studies didn’t turn up anything significant even at those levels of exposure.
I’m sure more studies have been done since then (there were a lot of companies poised to pounce if DEET were found to be really bad, esp if it were to be pulled off the market) so I wonder - what’s the latest, 30 years later?

The connection is arbovirus (arthropod-borne virus) transmitted by mostly mosquitoes and ticks where I'm at. DEET is the active repellant (i.e. Deep Woods Off). Applied to the skin or clothing to keep the biting critters away. We use it when we're off road with the dog(s) or out playing golf.

Permethrin impregnated treated clothing is also very effective … and it kills insects.

Probably influenced and paid for by the big DEET consortium.

What’s the connection to DEET?
I did a lot of reading about DEET and it’s tox testing (mainly on rats) back in the 90s when the Company I was VP of, was bought by Wisconsin Pharmacal (now “Pharmacal”)
J&J was “big DEET” at the time … don’t know if that has changed, but WP was a main player.
The toxicology lit was quite surprising. It took an equivalent of a 150lb adult human consuming (orally) an ounce a day of pure DEET for measurable symptoms to show up, headlined by “loss of appetite”. The neurological studies didn’t turn up anything significant even at those levels of exposure.
I’m sure more studies have been done since then (there were a lot of companies poised to pounce if DEET were found to be really bad, esp if it were to be pulled off the market) so I wonder - what’s the latest, 30 years later?

Yeah, DEET is surprisingly safe. Seems kind of counterintuitive given its nasty"chemical" smell and appearance.

Loss of appetite, you say? Sounds like drinking a can of DEET a day could be a safe off label weight loss drug. Maybe I'll give it try. Got a few pounds to lose.

Easy there, Beave! Rats are not a perfect analog to humans. I think the amount absorbed trans dermally by people using it as a repellent* is likely harmless, but I am willing to bet that drinking an ounce a day if 100% DEET is going to upset your tummy at the very least.

* it doesn’t actually repel insects, it confuses them. DEET renders their CO2 sensors inoperative, disabling their homing ability.

 

[Elixir]

ETA: don’t listen to me; I rarely get bitten by insects and rarely use chemical interventions. I’m more concerned with the stinging varieties.

 

[brewer]

Repeat Rectal Chlamydia Fell at a Seattle Clinic After Doctors Traded One Antibiotic Dose for a Week

Repeat and persistent rectal chlamydia infections fell measurably at a large Seattle sexual health clinic after it moved away from single-dose azithromycin in favor of a seven-day course of doxycycline, according to a 13-year analysis of electronic health records published in Open Forum Infectious Diseases.

Repeat Rectal Chlamydia Fell at a Seattle Clinic After Doctors Traded One Antibiotic Dose for a Week

A 13-year King County analysis found that repeat rectal chlamydia declined after a clinic guideline favored doxycycline over single-dose azithromycin.

www.medicaldaily.com

Maybe this should have been in the in your ass thread.