I really have to see Cloud Atlas seems very interesting.
I wonder how a GITS or Akira live action interpretation made in Hollywood could be multi-ethnic and give a firm and respectful nod to Japan (not just Asian Americans) without using plot gimmicks. I haven't seen the newest Wolverine to see the Japanese aspects.
With Akira you could have a white american kid who became fast friends with a Japanese kid while his parents were working there - or vice versa. The foreigner (Tetsuo or whichever name they change it to) would be bullied and protected by the other (Kaneda). It would be more challenging and interesting to have Tetsuo as white in Japan, than Japanese in America.
How to have Japan maintain as a plot point throughout would be a challenge. Maybe having some japanese scientists who know about the "Project" would be a good idea. Like Tadanobu Asano or someone a bit older or a Japanese version of the older scientist in Thor. Maybe having the americans take over the project and not have all the knowledge or respect/fear of it as the Japanese would work.
The American military would be an ok substitute the Japanese.
But I REALLY want to see the cult scene with the chanting. That was so epic! Do it even if you have american crazies.
And please keep the tribal impulse of the Akira soundtrack