I think the argument from design was more compelling to thinking people prior to the ToE. The seeming complexity and functionality of minute details of organisms. Locke starts out with what seems like a first cause argument, but then he goes onto specifically pointing to sentient beings like ourselves and saying that not only could we not have come from nothing, but the something must itself a being of some type to produce something else that is a being. That is a variant of argument from design. Thomas Jefferson referred to the beauty and order of the universe as the basis to infer a creator. The ToE seriously dismantles such arguments. Also, other areas of science including abiogenesis, naturally increasing complexity among inorganic molecules, and big bang cyclical cosmology undermine first cause arguments. Note the state of the evidence for these theories is largely a moot point. Arguments for god hinge upon there not even being any conceivable alternative to a creator creating the observed orderly complex universe. Thus, the mere existence of reasonable if yet unsubstantiated theories eliminates god as necessary conclusion, making it a conclusion only reachable by faith and not reason.