tupac chopra
Veteran Member
http://www.gmoseralini.org/wp-content/uploads/2013/01/Seralinial-AnswersCritics-FCT_2013.pdf
We would like to explain the choice of the strain of rat. This is
another redundant remark made by critics of our study design. We
recall that OECD norms (408, 452 and 453) are not prescriptive for
the strain of rat to be used. Sprague Dawley (SD) rats are subject to
spontaneous neoplasms and this property is supposed to invalidate
them being used as a model for carcinogenesis. However, on the
contrary, the fact that the SD strain develops tumors, hence has
led to it is preferentially used by some agencies such as for the National
Toxicology Program using it for 2-year carcinogenicity and
other long-term studies (King-Herbert et al., 2010). Indeed, it
would be a non-sense to study pathologies in a strain insensitive
to tumor formation. Long-term OECD guideline 452 even states
that rats and mice have been preferred as experimental model systems
because of their susceptibility to tumor induction. The same
reasoning is used for chronic progressive nephropathies (CPN)
developed by SD rats. The fact that the strain developed spontaneous
CPN with age (Hard and Khan, 2004) does not invalidate the
model as we looked at the difference in the chronology, age, number
and severity of CPN in comparison to controls.