Another unfortunate aspect of religion is in fact a theme of Dune, though to be fair I didn't really catch this the first couple times I read/watched Dune because it was buried in my disgust of being forced to read another excessively "chosen-one Blueblood hero" story, though to my defense I was young and hadn't been introduced to "hero isn't heroic" themes yet so I wasn't primed to catch it:
For some time, a variety of interests have attempted to commandeer and engineer fulfillment of a prophecy for political gain.
These are attempting to create a kind of "Jesus" in their own likeness: greedy, wealthy, without shame, and unrepentantly criminal. It seems almost like an engineered effort to release biblical scale plagues on the world through selective messaging about science and vaccination, an effort to release biblical scale wars, and rumors of wars, ahead of events that will, unfortunately, comport with Revelation.
Some wish to usurp the position of God as it exists "over" religion with themselves. In some respects the religious dogma exists for the sake of someone to step into it, as was the case in Dune.
We must be careful with people who would step into the position left behind after a prophet or a position of prophecy.
In some respects, I do wish there was a god of this world, but what I want is not the arbiter of what is. Instead, what is is arbitrated by the laws of physics, and the available subjects of observation. And what I see happening within physics is a slow turn of society by human actors towards unheard-of levels of suffering for the sake of gaining temporary control over the fires as the world burns because those with the power to response and just didn't want to listen to the reasoning as to why they should.
Hopefully we can pull it out of the fire on our own... I have my doubts, though.