Weapons of mass destruction
Bolton was instrumental in derailing a 2001 biological weapons conference in Geneva convened to endorse a UN proposal to enforce the 1972 Biological Weapons Convention. He argued that the plan would have jeopardized U.S. national security by allowing spot inspections of suspected U.S. weapons sites.
In May 2002, Bolton gave a speech entitled "Beyond the Axis of Evil" in response to President Bush's State of the Union Address (where Bush characterized Iran, Iraq, and North Korea as part of an "Axis of Evil"). Bolton added three more nations to be grouped with the aforementioned rogue states: Cuba, Libya, and Syria. Bolton said they were all "state sponsors of terrorism that are pursuing or who have the potential to pursue weapons of mass destruction (WMD) or have the capability to do so in violation of their treaty obligations." During his time as Under Secretary of State, Bolton "sought to block, and often succeeded in sabotaging" the negotiations that Secretary of State Colin Powell had conducted with North Korea.
Also in 2002, Bolton is said to have flown to Europe to demand the resignation of Brazilian José Bustani, head of the Organisation for the Prohibition of Chemical Weapons (OPCW), and to have orchestrated his removal at a special session of the organization.[69] Bustani was deemed to be an obstacle in creating the case for the invasion of Iraq. The United Nations' highest administrative tribunal later condemned the action as an "unacceptable violation" of principles protecting international civil servants. Bustani had been unanimously re-elected for a four-year term—with strong U.S. support—in May 2000, and in 2001 was praised for his leadership by Colin Powell. According to Bustani, John Bolton demanded that he step down in 24 hours, adding, "We know where your children are."
He also pushed for reduced funding for the Nunn–Lugar Cooperative Threat Reduction program to halt the proliferation of nuclear materials. At the same time, he was involved in the implementation of the Proliferation Security Initiative, working with a number of countries to intercept the trafficking in weapons of mass destruction and in materials for use in building nuclear weapons.