A govt study predicts the USA will cease to be a net food exporter. The LA region is heded towards a drinking water supply problem unrelated to drought.
Ca agriculture wells have gone deep enough to be contaminated by salt water. So much water has been pumped in Az the land has sunk in some places.
Desalination to the rescue. It is, however, an energy-intensive process, with the best case of it being 3 - 5.5 kWh/m^3 from reverse osmosis. This is roughly comparable to freshwater pumped in from long distances, but locally-available freshwater goes much lower, to as low as 0.2 kWh/m^3.
One can avoid consuming a lot of water by doing drip irrigation, like with perforated hoses, and by doing xeriscaping, landscaping with dryness-tolerant plants.
Also, desalination is suited for intermittent energy sources like wind and solar -- and also for constant sources like nuclear. This is because one can easily store water that one does not need right away.