My own musings on the topic.
1. It's not hard to imagine H. sapiens developing the wherewithal to live in a space-ship for thousands of years. But being able to terraform a new world for permanent occupancy is much harder.
2. There may be no short-cut (hyperdrive, worm-hole) to improve on subliminal travel.
3. If sufficiently motivated and able to survive on a home world, we can imagine a civilization able to explore (at subliminal speeds) the galaxy, select targets for terraforming, maintain zoos of other lifeforms encountered, and so on. A fleet of mother-ships and lesser vehicles would inhabit the galaxy. It is possible that the species that originally conceived of this fleet is no longer existent, or unable to travel, but is replaced with one or more artificial (or encountered) life forms.
If average mother-ship replication rate is 8000 years, the fleet could grow a thousand-fold in 8 million years. Sustaining that replication rate might require exploiting many planets. There could then be as many mother-ships as stars in the Milky Way after 35 million years. Some ships might be directed at neighboring galaxies, but — unlike for useful intragalaxy signaling — communication with extragalactic probings would be lost.
4. How likely is it that a planet will develop life as advanced as, say, H. sapiens? This is not an easy question.
5. Many scientists guess that no complex life is impossible in our universe without the familiar C-N-O-H biochemistry. Sure there might be variations: Could a backbone other than phosphates provide the necessary structure for a reliable genome? There's a good paper on-line which lists alternatives, explains the utility of the phosphate backbone and so on. I'll track down the URL if there's interest. (Another worth-reading paper is Schrodinger's
What is Life?)
Is it not widely guessed that our Universe is one of many, ours having a particular Fine Structure Constant for example, while different universes have different FSCs? In the sequel we keep the FSC fixed at its observed value. Only a biochemistry as observed on Earth is plausible.
6. Nick Lane goes further and thinks that the submarine alkaline trickling vents are the only plausible way for life to originate!
7. From a clumsy reaction chamber — or more likely many chambers in contact — LUCA emerged on Earth, the common ancestor of Bacteria and Archaeotes. LUCA is a splendid life-form, with (a) a large number of enzymes and ribo-enzymes implementing the genetic code, and (b) three proteins which form a proton-driven ATP synthesizer. (We just mention the two "most impressive"; LUCA also had sodium anti-porters and FeS enzymes.) What are the odds that such an intricate and successful Goldilocks-like LUCA would evolve? I don't think there's an authoritative statistical analysis.
Note that Nick Lane prefers ATP synthase (the 3-protein complex with a rotating part) as a paragon over DNA. One rotation ports ten protons across the membrane (through the rotator) and assembles three ATP molecules from the ADP+P raw materials. The total mass of all ATP one of us produces (NOT subtracting its ADP residue) exceeds within SECONDS (or some preposterous such) the total mass of the human body.
So what is the chance that the early interactions will evolve into a cell as complex as LUCA? Astronomically against? Or inevitable? I dunno.
8. There is much other impressive evolution besides the ribosome/genetic code and ATP synthase. Especially impressive is the giant gulf from prokaryotes to sexual eukaryotes. The gulf from the simplest eukaryote to H. sapiens may be small in comparison. Odds against or inevitable? I dunno.
9. So what is the answer, the output of the Bayes Equation?
As I said in one of the Jesus threads, prior odds may be too hard to come by to be confident of any claim. If someone says 10
6 is probably not sufficient planets to expect finding advanced life, but 10
10 is, I'd question their objectivity.
10. One (very weird?) conjecture is that evolution may follow a goal-seeking path (cf,
Bernstein–Vazirani algorithm or Shor's algorithm or even tunnelling electrons in cellular respiration and photosynthesis) The relationship between such well known instances of what I call "goal-seeking" and retrocausality is unclear.
And, whatever we think about points 1 - 10, if the odds of life anywhere in the universe are so low that Zero is far most likely, with One living planet the distant 2nd-most likely, then we KNOW the unlikely One is the case, not the Zero!