Assassinations are generally the acts of nuts.
Yeah, being ignored by people you are appealing to to stop treating you like shit can drive you nuts.
Of course, they might be ignoring you because you believe irrationally that they are able to help, but refusing to; But then again, they might just be uncaring of your plight.
Understanding that assassins usually believe themselves to have a genuine grievance against their targets is a great deal more helpful in preventing future assassinations than simply declaring them to be “nuts”, particularly as such dismissiveness is often a major contributing factor in their escalating from merely angry, to murderously angry.