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Molnupiravir (development codes MK-4482 and EIDD-2801) is an experimental antiviral drug which is orally active and was developed for the treatment of influenza. It is a prodrug of the synthetic nucleoside derivative N4-hydroxycytidine, and exerts its antiviral action through introduction of copying errors during viral RNA replication.
The drug was developed at Emory University by the university's drug innovation company, Drug Innovation Ventures at Emory (DRIVE). It was then acquired by Miami-based company Ridgeback Biotherapeutics, who later partnered with Merck & Co. to develop the drug further.
In April 2020, a whistleblower complaint by former Head of US Biomedical Advanced Research and Development Authority (BARDA) Rick Bright revealed concerns over providing funding for the further development of molnupiravir due to similar drugs having mutagenic (DNA damaging) properties.[3] A previous company, Pharmasset, that had investigated the drug's active ingredient had abandoned it. These claims were denied by George Painter, CEO of DRIVE, noting that toxicity studies on molnupiravir had been carried out and data provided to regulators in the US and UK, who permitted safety studies in humans to move forward in the spring of 2020. Also at this time, DRIVE and Ridgeback Biotherapeutics stated they planned future safety studies in animals
In late July 2020 Merck, which had been partnering with Ridgeback Biotherapeutics on developing the drug, announced its intention to move molnupiravir to late stage trials beginning in September 2020.[5] On October 19 2020, Merck began a one year Stage 2/3 trial focused on hospitalized patients.[6] In June 2021, the US Department of Health and Human Services committed to buy $1.2 billion worth of molnupiravir from Merck if it receives FDA approval
What's that supposed to mean?
Except the ones that died needlessly of course.But I do think there's too many antivaxxers for the majority to just run them over. I don't think it can be politically justified. Like it or not, anti-vaxxers are NOT some fringe group of extremists. They're a substantial group in society. A substantial minority. Their beliefs deserve respect for that reason alone. The last thing we want to do is to fuse them into a coherent political group and give them a victim card to play. I think that will cause more long term damage than the virus ever will. It's the job of democratically elected leaders to represent ALL of their constituents.
Welcome to the wonderful world of politics.
Yeah... the whole mutation argument has been explained a billion times and we needed to finish immunizing us so we could immunize the rest of the world, so that 30 year olds don't start dying at rates like the 80 year olds were. But we can't have nice things.As pandemic goes Covid-19 is quite mild. 4.3 million dead out of a total population of 7.8 billion isn't enough to warrant extreme measures curtailing political freedoms IMHO.
No, no they weren't. These people weren't running marathons, but many of them were alive and well enough.Especially not considering that the most of those who died were 80+ and were hanging on by a thread anyway.
The operative word is "most". Tens of thousands of perfectly healthy people also died. Children, etc. It's a tragedy.
I'm not saying it's nothing, or that Covid-19 isn't serious. Only that it could be a hell of a lot worse. In a situation like this, the severity of the situation is not enough to force anyone to do anything, IMHO. We can suggest. But I think using force is off the table. That includes bullying. Like drastically curtailing movement freedoms or requiring testing every couple of days. We need to leave anti-vaxxers the fuck alone now.
The only thing I think it warranted, given the situation, is to ask anti-vaxxers nicely and try to convince them to get with the program and join team reality. And if they don't, I think we need to accept it and stop nagging them. It sucks. But it is what it is.
Yes, we need to come up with compelling arguments to persuade the people that think the Democrats were running a child sex ring out of a pizzeria. Not enough of them are dying, so they don't care. You can't change apathy's mind without a lot of time.
So here we are, sorry the economy isn't getting better quicker, sorry those people died, sorry the health care professionals only got a breather instead of seeing the pandemic dropped to its knees in the US. We need to coddle people who aren't taking the vaccine because of assholes on the Internet, Cable News, and the AM Radio, by not only allowing them not to be vaccinated, but to not have to deal with any consequence of that decision they freely made. What's that called, oh yeah, tyranny of the minority.
Respecting the views of 20% of the population isn't to coddle them. These are sane reasonably well adjusted normal people who have reached another conclusion than you. Framing the the majority refraining from tyranny as the tyranny of the minority is stupid. Unless they're in control of the military, they're not going to terrorize anybody into obedience.
Not just hospitals but a lot of health care facilities. In my opinion, ALL ethical health care facilities mandate for all employees with exceptions for those with a valid medical reason to not be vaccinated. My employer mandates flu vaccines annually and also Hep B if you haven't already been vaccinated. They have mandated COVID19 since the vaccines became available. All these vaccinations are done in the work place, on company time. It's an expectation, just as it's an expectation that children are vaccinated against various illnesses before attending school or daycare. Or college.
Don't forget the military mandates all kinds of inoculations.
Yeah, that last sentence you state comes out with the same exclamation as if your were to say, I think everyone should eat enough fruits and veggies.This thread is actually an excellent example of the situation for anti-vaxxers. The majority is so convinced they are right that they forget the most basic aspects and the foundation of liberal democracy. When you lose the argument you turn it around and claim you won it with the knowledge that those who agree with your scientific position will slap you on the back and support you. Is it because you are feeling guilty, perhaps?
I agree with your scientific position. I think everyone should get vaccinated.
Don't make the mistake that I don't understand the seriousness of the situation. I'm not defending the rights of anti-vaxxers because I don't think we have anything to worry about, or that I think they may be right. I think they're wrong. I do think we have a lot to worry about. Millions have died. Many more will die before this is over. I think it's a catastrophe that so many chose not to get vaccinated. I'm also NOT a libertarian. I'm not for liberty no matter the cost. I do think personal freedoms can be curtailed in extreme situations. I think the state can seize personal property in some cases. I'm quite lefty. I'm NOT on team TSwizzle. I think he's wrong.
But I do think there's too many antivaxxers for the majority to just run them over. I don't think it can be politically justified. Like it or not, anti-vaxxers are NOT some fringe group of extremists. They're a substantial group in society. A substantial minority. Their beliefs deserve respect for that reason alone. The last thing we want to do is to fuse them into a coherent political group and give them a victim card to play. I think that will cause more long term damage than the virus ever will. It's the job of democratically elected leaders to represent ALL of their constituents.
As pandemic goes Covid-19 is quite mild. 4.3 million dead out of a total population of 7.8 billion isn't enough to warrant extreme measures curtailing political freedoms IMHO. Especially not considering that the most of those who died were 80+ and were hanging on by a thread anyway. I'm not saying it's nothing, or that Covid-19 isn't serious. Only that it could be a hell of a lot worse. In a situation like this, the severity of the situation is not enough to force anyone to do anything, IMHO. We can suggest. But I think using force is off the table. That includes bullying. Like drastically curtailing movement freedoms or requiring testing every couple of days. We need to leave anti-vaxxers the fuck alone now.
The only thing I think it warranted, given the situation, is to ask anti-vaxxers nicely and try to convince them to get with the program and join team reality. And if they don't, I think we need to accept it and stop nagging them. It sucks. But it is what it is.
I do see young people as different from adults. Artificially tweaking their developing bodies isn't the same as doing so to a fully developed adult. They have so much life ahead of them. Using extra care before giving them such a shot makes very good sense to me.
We have decades of experience with other immunizations, like polio and rubella and tetanus and such. That's just not true of this one. I'm fine with CDC recommendations on the subject.
Tom
It’s not about some “right” to have parents say what their kids can wear…. It never was.
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The fascist government makes me wear pants in public.
Where do they get that right?
The fascist government makes me wear pants in public.
Where do they get that right?
1) The US government does not make you wear pants. That's purely a matter of state law.
2) I consider it government overreach in most situations.
Back in May when it looked like vaccinations would go smoothly I got tickets for my two boys and me to go see the Dead and Company at the Xfinity Center in Mansfield MA on Sept 2 and 3. 19K capacity.
This is a mostly outside venue but there are still seat assignments. We are in the open air sections. We are vaccinated but my wife might be home from Canada then finally and she has not been able to get the shots in Canada. So she would be vulnerable and we know that there are breakthroughs and none of us want to get it.
There are many outside concerts around Boston this summer. Concerts at Fenway Park and the Xfinity Center. I'm watching the news on anything about the risks.
I am preparing myself that I will probably decide that I need to just eat the $800 I spend on the tickets if I think that I don't want to risk it.
And FUCK the anti-vaxers. Make them stay home.
California just mandated that all employees of school districts provide proof of vaccination or have weekly tests. I can not be happier. I teach in a middle school in CA. We have been in school now for 4 weeks; we are one of the earliest school districts in starting the year and oddly have not been in the news. We have multiple cases of positive tests of students at most if not all schools. Masks are mandated indoors with students present, but optional without students if all adults are vaccinated. The kicker is vaccination is medical history so we can not ask if another teacher is vaccinated. Mostly we accept that we are working with colleagues who are educated and have done the right thing; get vaccinated. But, I know from inquiries into the rights of employees under the union that I have on my campus teachers who are not vaccinated and are seeking exemptions to the requirement for masks indoors.
Why would you want to be in a classroom with 30+ students unvaccinated and without a mask?
I have 2 students in quarantine because they have tested positive for Covid. I know this because when they test positive I have to provide a list of students who sit within 6 feet of them in class.
I have to return to the hell of virtual meetings for the parent open house tomorrow. I am done with talking to computer screens as part of my job.
If people do not want to get vaccinated they can suffer the social ostracism. I am done with suffering the stupidity of the scientifically illiterate.
Bring on the vaxID. I will proudly show mine. Hell I took a pic of my vax card and have it on my phone to show proof. I have the fax record of my son schools required and I don’t see how this is different.
Edited to correct typo x2
Again, you state that, without any citations.The operative word is "most". Tens of thousands of perfectly healthy people also died. Children, etc. It's a tragedy.
Yes it is. It is coddling a ranting and raving toddler and giving into their demand. They ain't learnin' and their behavior is being normalized. Kind of what makes them a brat.Respecting the views of 20% of the population isn't to coddle them.Yes, we need to come up with compelling arguments to persuade the people that think the Democrats were running a child sex ring out of a pizzeria. Not enough of them are dying, so they don't care. You can't change apathy's mind without a lot of time.
So here we are, sorry the economy isn't getting better quicker, sorry those people died, sorry the health care professionals only got a breather instead of seeing the pandemic dropped to its knees in the US. We need to coddle people who aren't taking the vaccine because of assholes on the Internet, Cable News, and the AM Radio, by not only allowing them not to be vaccinated, but to not have to deal with any consequence of that decision they freely made. What's that called, oh yeah, tyranny of the minority.
Not me... peer reviewed professionals. This isn't about me. Other than how their decisions are fucking with my options and my liberty.These are sane reasonably well adjusted normal people who have reached another conclusion than you.
They have a hold on the economy spigot at the moment. Their decisions are directly impacting the lives of 300+ million Americans.Framing the the majority refraining from tyranny as the tyranny of the minority is stupid. Unless they're in control of the military, they're not going to terrorize anybody into obedience.
Cite?Respecting the views of 20% of the population isn't to coddle them. These are sane reasonably well adjusted normal people who have reached another conclusion than you.
DrZoidberg, Your wishy-washy "liberalism" is annoying. We had mandatory vaccines before this pandemics.
And people generally do not have liberty to dump poison into rivers or in the air. The only complicating factor here is that vaccine is considered experimental. So unless you have never taken any kind of medication you have no right to refuse a vaccine which is way safer than the most drugs which require prescription.
I admit I find the latest sub-debate hard to follow. I thought of posing some questions ("Is it fascist to insist on vaccination for measles without a medical exemption?") but was afraid I'd get no answers. So just tell me if the following summary is more-or-less correct.
If the danger of Covid-19 is less than 0.87 on some scale (never mind the details) than only a fascist government would mandate vaccines or masks. But if the danger is greater than 0.87 then it is those refusing masks or vaccines who are the fascists. Is that about right?
There are millions of Republicans who still think Obama was born in Kenya. Are they "sane, normal and well-adjusted"?
Cite?Respecting the views of 20% of the population isn't to coddle them. These are sane reasonably well adjusted normal people who have reached another conclusion than you.
Wow, that's even rosier picture than I expected from you. You seems to be counting deaths only, when in reality we know that even mild cases of C19 are bad in a long run. 70% of all infections develop long, potentially lifelong complications.DrZoidberg, Your wishy-washy "liberalism" is annoying. We had mandatory vaccines before this pandemics.
And people generally do not have liberty to dump poison into rivers or in the air. The only complicating factor here is that vaccine is considered experimental. So unless you have never taken any kind of medication you have no right to refuse a vaccine which is way safer than the most drugs which require prescription.
You are committing the black and white fallacy. I can be cool about not censoring video game violence without actually hating children.
When Covid-19 we didn't know how dangerous it was. Draconic measures were justified.
When we knew how dangerous Covid-19 was, we calibrated measures of force to match the requirements. Also justified.
But now we have vaccines. Mortality rate in western countries has hit the floor. The health care systems are no longer at a risk of being overwhelmed. We have a good understanding of the epidemiology of Covid-19. Covid-19 is no longer a global emergency. It's a local emergency in those countries who haven't had max vaccinations yet. Now Covid-19 is in the bag of all the other diseases that kill people and we don't need to treat Covid-19 as a special category.
Just this spring and earlier I supported the use of force to protect people. But now I think that time has passed. It's time to return to normalcy. Without good reason it's not morally justified to force people, and we don't have good reason any more IMHO.
https://www.fallacyfiles.org/either...guments that,gray is an available alternative.
Here is my solution, you are allowed to refuse vaccination but then you lose access to any drug you might need in the future, including the ones which treat your C19 infection. These anti-vaxers who suddenly start believing in modern medicine after they got sick should just die without any help, period. That's what they all say before getting sick.
[removed] What a surprise that the Putin apologetic supports fascism.