lpetrich
Contributor
More ivermectin effects. I found that it attacks invertebrates other than arthropods and nematodes: annelids and mollusks.
Research on the degradation of ivermectin and its acute toxicity to seven aquatic organisms.
Effects of the Veterinary Pharmaceutical Ivermectin on Soil Invertebrates in Laboratory Tests | SpringerLink
On the effects of ivermectin on freshwater snails of medical and veterinary importance. - Abstract - Europe PMC
Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis | The Journal of Antibiotics - "Ivermectin can be considered a promising molluscicide, especially as it is more potent against infected snails than uninfected ones, although it has no impact on egg-masses"
Acute toxicity of ivermectin to the lugworm Arenicola marina - ScienceDirect - a marine polychaete annelid - "(10-day LC50 0.023 mg/kg dry weight of sediment, confidence limits 0.018 and 0.027 mg/kg)"
Environmental risk from dissolved ivermectin to marine organisms - ScienceDirect - "The 96 h LC50 of ivermectin to N. integer was 70 ng l−1, with 95% confidence limits of 44 ng l−1 and 96 ng l−1."
Research on the degradation of ivermectin and its acute toxicity to seven aquatic organisms.
Photobacterium phosphoreum = a bioluminescent bacterium, Chlorella vulgaris = one-celled green alga, Brachydanio rerio = zebrafish, Gambusia affinis = mosquitofish, Carassius auratus = goldfish, Macrobrachium rosenbergii = giant river prawn, Daphnia magna = water flea (a crustacean)The results showed no obviously toxicity to Photobacterium phosphoreum and the 96 h EC-50 to Chlorella vulgaris was 19.80 mg/L, it did not exhibit high toxicity. But the toxicity of IVM to Brachydanio rerio, Gambusia affinis, Carassius auratus, Macrobrachium rosenbergii and Daphnia magna were relatively higher, and date was 40.48 ug/L (96 h LC-50), 34.81 ug/L (96 h LC-50), 13.79 ug/L (96 h LC-50), 7.87 ug/L (96 h LC-50) and 4.81 ng/L (24 h LC-50) respectively. IVM would influence the aqua-biology obviously when the drug residue appeared in water environment, so it is necessary to learn more on ivermectin.
Effects of the Veterinary Pharmaceutical Ivermectin on Soil Invertebrates in Laboratory Tests | SpringerLink
Collembolan = springtail, a kind of wingless insectIn detail, three soil invertebrate species—the earthworm Eisenia fetida, the springtail Folsomia candida, and the predatory mite Hypoaspis aculeifer—were tested. The nominal concentrations of ivermectin mixed into the test substrate artificial soil was verified using residue analysis, which indicated that the test substance is persistent for at least up to 28 days. As expected when considering the mode of action of this substance, survival and reproduction of collembolans were clearly affected [LC50 = 8.4 mg/kg soil dry weight (dw); NOECrepro = 0.3 mg/kg soil (dw)]. Predatory mites reacted less sensitively [LC50 ≥ 31.6 mg/kg soil (dw); NOECrepro = 3.2 mg/kg soil (dw)]. Earthworm survival and reproduction were affected in the same order of magnitude as the predatory mites [LC50 ≥ 10 mg/kg soil (dw); NOECrepro = 2.5 mg/kg soil (dw)].
On the effects of ivermectin on freshwater snails of medical and veterinary importance. - Abstract - Europe PMC
Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis | The Journal of Antibiotics - "Ivermectin can be considered a promising molluscicide, especially as it is more potent against infected snails than uninfected ones, although it has no impact on egg-masses"
Acute toxicity of ivermectin to the lugworm Arenicola marina - ScienceDirect - a marine polychaete annelid - "(10-day LC50 0.023 mg/kg dry weight of sediment, confidence limits 0.018 and 0.027 mg/kg)"
Environmental risk from dissolved ivermectin to marine organisms - ScienceDirect - "The 96 h LC50 of ivermectin to N. integer was 70 ng l−1, with 95% confidence limits of 44 ng l−1 and 96 ng l−1."